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Our Foundation/Methylation/Wellness Nutrigenomic Panel, targets 25 genes to be analyzed for SNPs (single nucleotide polymorphisms). The report algorithms and customized software will take the patient’s genetic results and create nutritional and lifestyle recommendations along with recommended lab work and health precautions based upon SNP results and their clinical expertise. The built-in proprietary software takes out the guess work and allows the provider to recommend the proper nutrition and health advisements based on your DNA results.
VALUEThis product provides information about results for some health conditions that are mostly influenced by genetics, and for other health conditions where genetics, environment, and lifestyle all influence your disease risk.
LIMITATIONSThis Test, is NOT a diagnostic product. This product evaluates specific variants associated with different health conditions and medication response. It does NOT look at all possible genes or variants associated with each condition tested. This product does NOT evaluate for gene variants associated with conditions not included in the test.
• Methylation involves the addition of a "methyl" chemical group to a substrate
• Used in over 250 biochemical processes in the body
• Methylation is utilized in major functions of:
o Neurotransmitter production
o Cell turnover and repair
o Membrane function
o Energy (mitochondrial) function
• Problems with methylation will affect the cellular delivery, epigenetics and intra-cellular functionality of almost all cells.*
The term methylation describes a biochemical process that is utilized in the body for transport of nutrients, energy production and in gene modulation. In patients with decreased methylation activity (i.e. methylation deficiency), there are significant shortcomings in the ability to execute a variety of important chemical functions in the body. These shortcomings can leave the body unprotected from the everyday assault of environmental and infectious agents, sluggish in neurotransmitter production and slow to recover from inflammatory damage.
This shortfall can result in a wide range of medical conditions including neurological issues, such as seizures, migraines, dizziness, depression, anxiety, OCD, ADD/ADHD, developmental delay, autism, dementias and memory issues, chronic persistent infections, auto-immune disease, neural tube defects, infertility and pregnancy complications. Appropriate supplementation with the proper methylated vitamins and nutrients will bypass the genetic and acquired deficits and restore appropriate function of the pathway resulting in improvement in these complicated syndromes. The proper functioning of the methylation cycle is essential for CRITICAL reactions in the body.
The methylation cycle is the ideal pathway to focus on for nutrigenomic analysis because the proper function of this pathway is essential for over 250 processes in the body.
• Methylenetetrahydrofolate reductase, or MTHFR, is a key regulatory enzyme in the metabolism of folate. It also refers to a specific gene that plays a major role in the body's methylation process. Both the enzyme and the gene have the same name, MTHFR. The gene's role is very complex, and recent discoveries have been focused around the MTHFR gene polymorphisms (or variants). These polymorphisms are often referred to as 'mutations' or 'defects' because of the problems they cause in the body.
• Most often when you hear someone talk about MTHFR, they are actually referring to one of the two common MTHFR gene mutations that causes this MTHFR enzyme to become imperfect and therefore much less effective.
• Simply stated, MTHFR most often refers to a genetic mutation that inhibits the body's ability to methylate or convert folic acid from the food we eat into Methylfolate.
• Methylfolate is most often referred to as the 'active' or usable form of folate that our cells require. Because the body's cells cannot actually use folic acid, it must first go through a metabolic pathway or 4-step conversion process to become Methylfolate before the cells can use it . It is this metabolic pathway that the MTHFR gene defect inhibits and cause methylation deficiencies and/or neuro-immune syndromes.
• The learnings about this gene defect have come out and taught us that there are as many as 50+ variants of the MTHFR gene. However, only two are considered 'common' defects that today’s MTHFR Blood Test checks for and are the: 677 and 1298 (discovered in 1995 and 2001).
• Normal / C677T - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)
• Normal / A1298C - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)
• A1298C / A1298C - Denoted as 1298CC - Much worse for the above problems (referred to as Homozygous)
• C677T / C677T - Denoted as 677TT - Similar to 1298CC plus heart disease, blood clots, and more (referred to as Homozygous)
• C677T / A1298C - Susceptible to all of the above and worse for strokes, heart disease, blood clots, etc. (referred to as Compound Heterozygous)
• Methylation issues like being unable to fully convert folic acid to the active, usable form of folate (methylfolate) can lead to a folate deficiency.
• Methylation issues can be behind why folate deficiency occurs, such as when there is an inadequate amount of folate, an increased need in the body for folate, or when the body loses folate faster than usual.
• No matter the case, folic acid, folate, or methylfolate issues can leave patients with feelings of fatigue, irritability, sleep issues, anxiety, brain fog, and aches and pains.
• These side effects can be greater for some, leading to a diagnosis of fibromyalgia, an autoimmune disease, or anemia. Symptoms can be worsened by excessive alcohol consumption, kidney problems, and certain medications.
• Methylfolate (5MTHF) contributes to the creation of neurotransmitters and immune cells, processing of hormones, production of energy, and detoxing chemicals and toxins.
• Since the methylation cycle interacts with over 200 processes in the body, it’s important in find out where your methylation issues lie to understand the root of the problem. That way, you can determine the best course of action to better health rather than trying to solve a slew of side effects.
• Genetic testing for methylation can help doctors and their patients better understand where in the methylation cycle an issue may be occurring because of genetic variants.If folate deficiency is determined as the cause, or aggravating factor, of your methylation issues, a folate-rich diet may be enough to get you back on course. Vegetables like romaine lettuce, spinach, cauliflower, broccoli, beets, and lentils are great sources of natural folate. Additionally, be aware not to overcook your food, which can destroy the vitamins and nutrients, diminishing the nutritional value. For women trying to get pregnant and those struggling with more complex or severe issues in the methylation cycle, an orally supplement of active folate like Methyl Folate Plus may be needed.
Perfect marriage of Innovative DNA Testing and Proprietary Interpretation Software.
Our Nutrigenomics tests, are much more than your typical laboratory’s DNA Genomic Test. In fact, our system is the perfect marriage between forward thinking Interpretation Software and Innovative Nutrigenomics Testing. In addition to being the most comprehensive DNA Nutrigenomics test available, the real magic lies within our proprietary SNP Interpretation software.
Our innovative software, takes the guesswork out of the physician’s results interpretation, as it links any identified SNPs to the recommended nutritional support that lends the greatest potential for the most optimal patient outcome. This software provides a detail and a summary, showing highly recommended nutritional support therapeutics, the nutritional or pharmacological support best left to the provider’s discretion, lifestyle recommendations, as well as any suggested additional laboratory testing one should consider.
This saves the provider valuable time that could be better spent on patient care, rather than looking up specific SNPs and the associated supplemental support. Additionally, the concise format of our report provides an easy to understand outline to better ensure alignment between patient and provider.